Alternatives to INH chemoprophylaxis.

Also there is some concern about efficacy of rifampicin as single drug prophylaxis in contacts where the source is proved to be excreting INH resistant bacilli. A case of probable rifampicin failure in such situation is described(3) and hence recommendation for chemophophylaxis of confirmed INH resistance vary from rimampicin alone or rifampicin with ethambutol; both regimens for 9 months(4). INH and thiacetazone for chemoprophylaxis, cannot be recommended as thiacetazone is a less potent drug and have more side effects and a higher primary resistance in Asians including Indians(5).